Prostatic Acid Phosphatase Reduces Thermal Sensitivity and Chronic Pain Sensitization by Depleting Phosphatidylinositol 4,5-Bisphosphate

Prostatic acid phosphatase (PAP) is expressed in nociceptive dorsal root ganglion (DRG) neurons, functions as an ectonucleotidase, and generates adenosine extracellularly. Here, we found that PAP inhibits noxious thermal sensitivity and sensitization that is associated with chronic pain through sust...

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Autores principales: Sowa, Nathaniel A., Street, Sarah E., Vihko, Pirkko, Zylka, Mark J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920622/
https://ncbi.nlm.nih.gov/pubmed/20685973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2162-10.2010
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