Evaluation of Substrate and Inhibitor Binding to Yeast and Human Isoprenylcysteine Carboxyl Methyltransferases (Icmts) using Biotinylated Benzophenone-containing Photoaffinity Probes

Isoprenylcysteine carboxyl methyltransferases (Icmts) are a class of integral membrane protein methyltransferases localized to the endoplasmic reticulum (ER) membrane in eukaryotes. The Icmts from human (hIcmt) and S. cerevisae (Ste14p) catalyze the α-carboxyl methyl esterification step in the post-...

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Hlavní autoři: Hahne, Kalub, Vervacke, Jeffery, Shrestha, Liza, Donelson, James L., Gibbs, Richard A., Distefano, Mark D., Hrycyna, Christine A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718205/
https://ncbi.nlm.nih.gov/pubmed/22634004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.05.089
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