S-Farnesyl-Thiopropionic Acid Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase

[Image: see text] We report the design and synthesis of novel FTPA-triazole compounds as potent inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt), through a focus on thioether and isoprenoid mimetics. These mimetics were coupled utilizing a copper-assisted cycloaddition to assemble t...

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Bibliografiske detaljer
Main Authors: Bergman, Joel A., Hahne, Kalub, Song, Jiao, Hrycyna, Christine A., Gibbs, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2011
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387282/
https://ncbi.nlm.nih.gov/pubmed/22754607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200106d
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