Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning

Metabotropic glutamate receptor 5 (mGluR5) plays important roles in modulating neural activity and plasticity and has been associated with several neuropathological disorders. Previous work has shown that genetic ablation or pharmacological inhibition of mGluR5 disrupts fear extinction and spatial r...

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Detalhes bibliográficos
Main Authors: Xu, Jian, Zhu, Yongling, Kraniotis, Stephen, He, Qionger, Marshall, John J., Nomura, Toshihiro, Stauffer, Shaun R., Lindsley, Craig W., Conn, P. Jeffrey, Contractor, Anis
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718201/
https://ncbi.nlm.nih.gov/pubmed/23869026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.031666.113
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