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Nucleotide Release Sequences in the Protein Kinase SRPK1 Accelerate Substrate Phosphorylation()

Protein kinases are essential signaling enzymes that transfer phosphates from bound ATP to select amino acids in protein targets. For most kinases, the phosphoryl transfer step is highly efficient while the rate-limiting step for substrate processing involves slow release of the product ADP. It is g...

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Bibliographic Details
Main Authors: Aubol, Brandon E., Plocinik, Ryan M., McGlone, Maria L., Adams, Joseph A.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718016/
https://ncbi.nlm.nih.gov/pubmed/22839969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300876h
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