Suppression of Epithelial-to-Mesenchymal Transitioning Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue Toward Functional Insulin-Producing β-Like Cells

Because of the lack of tissue available for islet transplantation, new sources of β-cells have been sought for the treatment of type 1 diabetes. The aim of this study was to determine whether the human exocrine-enriched fraction from the islet isolation procedure could be reprogrammed to provide add...

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Bibliographische Detailangaben
Hauptverfasser: Lima, Maria João, Muir, Kenneth R., Docherty, Hilary M., Drummond, Robert, McGowan, Neil W.A., Forbes, Shareen, Heremans, Yves, Houbracken, Isabelle, Ross, James A., Forbes, Stuart J., Ravassard, Philippe, Heimberg, Harry, Casey, John, Docherty, Kevin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2013
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717833/
https://ncbi.nlm.nih.gov/pubmed/23610058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1256
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