Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture

A replenishable source of insulin-producing cells has the potential to cure type 1 diabetes. Attempts to culture and expand pancreatic β-cells in vitro have resulted in their transition from insulin-producing epithelial cells to mesenchymal stromal cells (MSCs) with high proliferative capacity but d...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Muir, Kenneth R., Lima, Maria João, Docherty, Hilary M., McGowan, Neil W. A., Forbes, Shareen, Heremans, Yves, Forbes, Stuart J., Heimberg, Harry, Casey, John, Docherty, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601732/
https://ncbi.nlm.nih.gov/pubmed/26457418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140352
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