Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer

Genetic alterations activating K-RAS and PI3K/AKT signaling are also known to induce the activity of mTOR kinase through TORC1 and TORC2 complexes in human pancreatic ductal adenocarcinoma (PDAC). Here, we determined the effects of the dual PI3K and mTOR inhibitor, NVP-BEZ235 (BEZ235), and the pan-h...

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Autors principals: Venkannagari, Sreedhar, Fiskus, Warren, Peth, Karissa, Atadja, Peter, Hidalgo, Manuel, Maitra, Anirban, Bhalla, Kapil N.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2012
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717802/
https://ncbi.nlm.nih.gov/pubmed/23232026
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