Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates

OBJECTIVE: During coagulation, factor IX (FIX) is activated by two distinct mechanisms mediated by the active proteases of either factors VII (FVIIa) or XI (FXIa). Both coagulation factors may contribute to thrombosis; factor XI, however, plays only a limited role in the arrest of bleeding. Therefor...

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Bibliografiske detaljer
Main Authors: Crosby, Jeffrey R., Marzec, Ulla, Revenko, Alexey S., Zhao, Chenguang, Gao, Dacao, Matafonov, Anton, Gailani, David, MacLeod, A. Robert, Tucker, Erik I., Gruber, Andras, Hanson, Stephen R., Monia, Brett P.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717325/
https://ncbi.nlm.nih.gov/pubmed/23559626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.301282
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