Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates

OBJECTIVE: During coagulation, factor IX (FIX) is activated by two distinct mechanisms mediated by the active proteases of either factors VII (FVIIa) or XI (FXIa). Both coagulation factors may contribute to thrombosis; factor XI, however, plays only a limited role in the arrest of bleeding. Therefor...

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Main Authors: Crosby, Jeffrey R., Marzec, Ulla, Revenko, Alexey S., Zhao, Chenguang, Gao, Dacao, Matafonov, Anton, Gailani, David, MacLeod, A. Robert, Tucker, Erik I., Gruber, Andras, Hanson, Stephen R., Monia, Brett P.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717325/
https://ncbi.nlm.nih.gov/pubmed/23559626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.301282
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