Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

Recent studies indicate that the plasma contact system plays an important role in thrombosis, despite being dispensable for hemostasis. For example, mice deficient in coagulation factor XII (fXII) are protected from arterial thrombosis and cerebral ischemia-reperfusion injury. We demonstrate that se...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Revenko, Alexey S., Gao, Dacao, Crosby, Jeff R., Bhattacharjee, Gourab, Zhao, Chenguang, May, Chris, Gailani, David, Monia, Brett P., MacLeod, A. Robert
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425441/
https://ncbi.nlm.nih.gov/pubmed/21821705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-355248
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