Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice

Vascular abnormalities and inflammation are found in many Alzheimer disease (AD) patients, but whether these changes play a causative role in AD is not clear. The factor XII (FXII) –initiated contact system can trigger both vascular pathology and inflammation and is activated in AD patients and AD m...

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Vydáno v:Blood
Hlavní autoři: Chen, Zu-Lin, Revenko, Alexey S., Singh, Pradeep, MacLeod, A. Robert, Norris, Erin H., Strickland, Sidney
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418637/
https://ncbi.nlm.nih.gov/pubmed/28242605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-11-753202
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