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Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice
Vascular abnormalities and inflammation are found in many Alzheimer disease (AD) patients, but whether these changes play a causative role in AD is not clear. The factor XII (FXII) –initiated contact system can trigger both vascular pathology and inflammation and is activated in AD patients and AD m...
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| Veröffentlicht in: | Blood |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5418637/ https://ncbi.nlm.nih.gov/pubmed/28242605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-11-753202 |
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