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Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice

Vascular abnormalities and inflammation are found in many Alzheimer disease (AD) patients, but whether these changes play a causative role in AD is not clear. The factor XII (FXII) –initiated contact system can trigger both vascular pathology and inflammation and is activated in AD patients and AD m...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Chen, Zu-Lin, Revenko, Alexey S., Singh, Pradeep, MacLeod, A. Robert, Norris, Erin H., Strickland, Sidney
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418637/
https://ncbi.nlm.nih.gov/pubmed/28242605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-11-753202
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