Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo

The IL-6/JAK/STAT pathway is a key signal transduction pathway implicated in the pathogenesis of many human cancers, suggesting that kinase inhibitors targeting JAK/STAT3 may have a broad spectrum of antitumor activity. AZD1480, a pharmacological JAK1/2 inhibitor, exhibits anti-tumor potency in mult...

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Hlavní autoři: Yan, Shuang, Li, Zhijie, Thiele, Carol J
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2013
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717306/
https://ncbi.nlm.nih.gov/pubmed/23531921
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