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Pharmacokinetics-Pharmacodynamics of Tazobactam in Combination with Ceftolozane in an In Vitro Infection Model

Despite β-lactamase inhibitors being available for clinical use for nearly 30 years, a paucity of data exists describing the pharmacokinetic-pharmacodynamic (PK-PD) determinants of efficacy for these agents. Herein, we describe dose fractionation studies designed to determine the exposure measure mo...

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Detalhes bibliográficos
Main Authors: VanScoy, Brian, Mendes, Rodrigo E., Nicasio, Anthony M., Castanheira, Mariana, Bulik, Catharine C., Okusanya, Olanrewaju O., Bhavnani, Sujata M., Forrest, Alan, Jones, Ronald N., Friedrich, Lawrence V., Steenbergen, Judith N., Ambrose, Paul G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716129/
https://ncbi.nlm.nih.gov/pubmed/23629705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02513-12
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