Relationship between Ceftolozane-Tazobactam Exposure and Selection for Pseudomonas aeruginosa Resistance in a Hollow-Fiber Infection Model

It is important to understand the relationship between antibiotic exposure and the selection of drug resistance in the context of therapy exposure. We sought to identify the ceftolozane-tazobactam exposure necessary to prevent the amplification of drug-resistant bacterial subpopulations in a hollow-...

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Bibliographic Details
Main Authors: VanScoy, Brian D., Mendes, Rodrigo E., Castanheira, Mariana, McCauley, Jennifer, Bhavnani, Sujata M., Jones, Ronald N., Friedrich, Lawrence V., Steenbergen, Judith N., Ambrose, Paul G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187943/
https://ncbi.nlm.nih.gov/pubmed/25070105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02310-13
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