Relationship between Ceftolozane-Tazobactam Exposure and Selection for Pseudomonas aeruginosa Resistance in a Hollow-Fiber Infection Model

It is important to understand the relationship between antibiotic exposure and the selection of drug resistance in the context of therapy exposure. We sought to identify the ceftolozane-tazobactam exposure necessary to prevent the amplification of drug-resistant bacterial subpopulations in a hollow-...

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Detalhes bibliográficos
Main Authors: VanScoy, Brian D., Mendes, Rodrigo E., Castanheira, Mariana, McCauley, Jennifer, Bhavnani, Sujata M., Jones, Ronald N., Friedrich, Lawrence V., Steenbergen, Judith N., Ambrose, Paul G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187943/
https://ncbi.nlm.nih.gov/pubmed/25070105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02310-13
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