Pioglitazone Improves Reversal Learning and Exerts Mixed Cerebrovascular Effects in a Mouse Model of Alzheimer’s Disease with Combined Amyloid-β and Cerebrovascular Pathology

Animal models of Alzheimer’s disease (AD) are invaluable in dissecting the pathogenic mechanisms and assessing the efficacy of potential new therapies. Here, we used the peroxisome proliferator-activated receptor gamma agonist pioglitazone in an attempt to rescue the pathogenic phenotype in adult (1...

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Библиографические подробности
Главные авторы: Papadopoulos, Panayiota, Rosa-Neto, Pedro, Rochford, Joseph, Hamel, Edith
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715495/
https://ncbi.nlm.nih.gov/pubmed/23874687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068612
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