Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone

The roles of chronic brain hypoperfusion and transforming growth factor-beta 1 (TGF-β1) in Alzheimer's disease (AD) are unresolved. We investigated the interplay between TGF-β1, cerebrovascular function, and cognition using transgenic TGF mice featuring astrocytic TGF-β1 overexpression. We furt...

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Detalhes bibliográficos
Main Authors: Nicolakakis, Nektaria, Aboulkassim, Tahar, Aliaga, Antonio, Tong, Xin-Kang, Rosa-Neto, Pedro, Hamel, Edith
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049484/
https://ncbi.nlm.nih.gov/pubmed/20571524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.78
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