Transgenic Mice Overexpressing APP and Transforming Growth Factor-β1 Feature Cognitive and Vascular Hallmarks of Alzheimer’s Disease

High brain levels of amyloid-β (Aβ) and transforming growth factor-β1 (TGF-β1) have been implicated in the cognitive and cerebrovascular alterations of Alzheimer’s disease (AD). We sought to investigate the impact of combined increases in Aβ and TGF-β1 on cerebrovascular, neuronal, and mnemonic func...

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Detalhes bibliográficos
Main Authors: Ongali, Brice, Nicolakakis, Nektaria, Lecrux, Clotilde, Aboulkassim, Tahar, Rosa-Neto, Pedro, Papadopoulos, Panayiota, Tong, Xin-Kang, Hamel, Edith
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993264/
https://ncbi.nlm.nih.gov/pubmed/21088218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100339
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