Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist

Accumulating evidence suggests that cerebrovascular dysfunction is an important factor in the pathogenesis of Alzheimer's disease (AD). Using aged (∼16 months) amyloid precursor protein (APP) transgenic mice that exhibit increased production of the amyloid-β (Aβ) peptide and severe cerebrovascu...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Nicolakakis, Nektaria, Aboulkassim, Tahar, Ongali, Brice, Lecrux, Clotilde, Fernandes, Priscilla, Rosa-Neto, Pedro, Tong, Xin-Kang, Hamel, Edith
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670922/
https://ncbi.nlm.nih.gov/pubmed/18784309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3348-08.2008
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