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Losartan improves cerebrovascular function in a mouse model of Alzheimer's disease with combined overproduction of amyloid-β and transforming growth factor-β1

Alterations of the renin-angiotensin system have been implicated in the pathogenesis of Alzheimer's disease. We tested the efficacy of losartan (10 mg/kg/day for three months), a selective angiotensin II type 1 receptor antagonist, in alleviating cerebrovascular and cognitive deficits in double...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Papadopoulos, Panayiota, Tong, Xin-Kang, Imboden, Hans, Hamel, Edith
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464692/
https://ncbi.nlm.nih.gov/pubmed/27389178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16658489
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