Role of CTCF Protein in Regulating FMR1 Locus Transcription

Fragile X syndrome (FXS), the leading cause of inherited intellectual disability, is caused by epigenetic silencing of the FMR1 gene, through expansion and methylation of a CGG triplet repeat (methylated full mutation). An antisense transcript (FMR1-AS1), starting from both promoter and intron 2 of...

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Bibliographische Detailangaben
Hauptverfasser: Lanni, Stella, Goracci, Martina, Borrelli, Loredana, Mancano, Giorgia, Chiurazzi, Pietro, Moscato, Umberto, Ferrè, Fabrizio, Helmer-Citterich, Manuela, Tabolacci, Elisabetta, Neri, Giovanni
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715420/
https://ncbi.nlm.nih.gov/pubmed/23874213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003601
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