Genome-wide methylation analysis demonstrates that 5-aza-2-deoxycytidine treatment does not cause random DNA demethylation in fragile X syndrome cells

BACKGROUND: Fragile X syndrome (FXS) is caused by CGG expansion over 200 repeats at the 5′ UTR of the FMR1 gene and subsequent DNA methylation of both the expanded sequence and the CpGs of the promoter region. This epigenetic change causes transcriptional silencing of the gene. We have previously de...

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Vydáno v:Epigenetics Chromatin
Hlavní autoři: Tabolacci, Elisabetta, Mancano, Giorgia, Lanni, Stella, Palumbo, Federica, Goracci, Martina, Ferrè, Fabrizio, Helmer-Citterich, Manuela, Neri, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806452/
https://ncbi.nlm.nih.gov/pubmed/27014370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-016-0060-x
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