DNA Methylation, Mechanisms of FMR1 Inactivation and Therapeutic Perspectives for Fragile X Syndrome

Among the inherited causes of intellectual disability and autism, Fragile X syndrome (FXS) is the most frequent form, for which there is currently no cure. In most FXS patients, the FMR1 gene is epigenetically inactivated following the expansion over 200 triplets of a CGG repeat (FM: full mutation)....

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Nobile, Veronica, Pucci, Cecilia, Chiurazzi, Pietro, Neri, Giovanni, Tabolacci, Elisabetta
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920310/
https://ncbi.nlm.nih.gov/pubmed/33669384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11020296
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