Resumption of High-dose Methotrexate after Acute Kidney Injury and Glucarpidase Use in Pediatric Oncology Patients

BACKGROUND: High-dose methotrexate (HDMTX)-induced acute kidney injury is a rare but life-threatening complication. The methotrexate rescue agent glucarpidase rapidly hydrolyzes methotrexate to inactive metabolites. We retrospectively reviewed glucarpidase use in pediatric cancer patients at our ins...

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Main Authors: Christensen, Anthony M., Pauley, Jennifer L., Molinelli, Alejandro R., Panetta, John C., Ward, Deborah A., Stewart, Clinton F., Hoffman, James M., Howard, Scott C., Pui, Ching-Hon, Pappo, Alberto S., Relling, Mary V., Crews, Kristine R.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713608/
https://ncbi.nlm.nih.gov/pubmed/22252903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.27378
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