Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments

PURPOSE: It is advantageous to individualize high-dose methotrexate (HDMTX) to maintain adequate exposure while minimizing toxicities. Previously, we accomplished this through within-course dose adjustments. METHODS: In this study, we evaluated a strategy to individualize HDMTX based on clearance of...

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Detalhes bibliográficos
Main Authors: Pauley, Jennifer L., Panetta, John C., Crews, Kristine R., Pei, Deqing, Cheng, Cheng, McCormick, John, Howard, Scott C., Sandlund, John T., Jeha, Sima, Ribeiro, Raul, Rubnitz, Jeffrey, Pui, Ching-Hon, Evans, William E., Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719000/
https://ncbi.nlm.nih.gov/pubmed/23760811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-013-2206-x
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