Effect of Allopurinol versus Urate Oxidase on Methotrexate Pharmacokinetics in Children with Newly Diagnosed Acute Lymphoblastic Leukemia

BACKGROUND: Allopurinol and urate oxidase are both effective in preventing or treating hyperuricemia during remission induction therapy for lymphoid malignancies, but their effect on concomitant anticancer drug therapy has not been compared. METHODS: We compared plasma methotrexate pharmacokinetics...

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Main Authors: Crews, Kristine R., Zhou, Yinmei, Pauley, Jennifer L., Howard, Scott C., Jeha, Sima, Relling, Mary V., Pui, Ching-Hon
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846832/
https://ncbi.nlm.nih.gov/pubmed/19834958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.24681
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