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Effect of Allopurinol versus Urate Oxidase on Methotrexate Pharmacokinetics in Children with Newly Diagnosed Acute Lymphoblastic Leukemia
BACKGROUND: Allopurinol and urate oxidase are both effective in preventing or treating hyperuricemia during remission induction therapy for lymphoid malignancies, but their effect on concomitant anticancer drug therapy has not been compared. METHODS: We compared plasma methotrexate pharmacokinetics...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2846832/ https://ncbi.nlm.nih.gov/pubmed/19834958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.24681 |
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