Prophylactic Trimethoprim-sulfamethoxazole does not affect pharmacokinetics or pharmacodynamics of methotrexate

Trimethoprim-sulfamethoxazole (TMP/SMX) is used as prophylaxis against Pneumocystis jiroveci during chemotherapy. Many groups recommend withholding TMP/SMX during high-dose methotrexate (HDMTX) for concerns that it will delay methotrexate clearance. We compared methotrexate exposure following HDMTX...

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Detalhes bibliográficos
Publicado no:J Pediatr Hematol Oncol
Main Authors: Watts, Courtney S., Sciasci, Joseph N., Pauley, Jennifer L., Panetta, John C., Pei, Deqing, Cheng, Cheng, Christensen, Caroline M., Mikkelsen, Torben S., Pui, Ching-Hon, Jeha, Sima, Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955728/
https://ncbi.nlm.nih.gov/pubmed/27322715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPH.0000000000000606
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