Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects

PURPOSE: Methotrexate plasma concentration is related to its clinical effects. Our aim was to identify the genetic basis of interindividual variability in methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: We performed a genome-wi...

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Bibliografiske detaljer
Main Authors: Treviño, Lisa R., Shimasaki, Noriko, Yang, Wenjian, Panetta, John C., Cheng, Cheng, Pei, Deqing, Chan, Diana, Sparreboom, Alex, Giacomini, Kathleen M., Pui, Ching-Hon, Evans, William E., Relling, Mary V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2009
Fag:
Original Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793040/
https://ncbi.nlm.nih.gov/pubmed/19901119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.20.4156
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