Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects

PURPOSE: Methotrexate plasma concentration is related to its clinical effects. Our aim was to identify the genetic basis of interindividual variability in methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: We performed a genome-wi...

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Hauptverfasser: Treviño, Lisa R., Shimasaki, Noriko, Yang, Wenjian, Panetta, John C., Cheng, Cheng, Pei, Deqing, Chan, Diana, Sparreboom, Alex, Giacomini, Kathleen M., Pui, Ching-Hon, Evans, William E., Relling, Mary V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2009
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Original Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793040/
https://ncbi.nlm.nih.gov/pubmed/19901119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.20.4156
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