Efficacy of Glucarpidase (Carboxypeptidase G2) in Patients with Acute Kidney Injury After High-Dose Methotrexate Therapy

STUDY OBJECTIVE: As the incidence rate of renal impairment is 2–10% for patients treatment with high-dose methotrexate , and renal impairment develops in 0–12.4% of patients treated for osteosarcoma, we sought to evaluate the efficacy of glucarpidase, a recently approved drug that rapidly hydrolyzes...

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Bibliographic Details
Main Authors: Widemann, Brigitte C., Schwartz, Stefan, Jayaprakash, Nalini, Christensen, Robbin, Pui, Ching-Hon, Chauhan, Nikhil, Daugherty, Claire, King, Thomas R., Rush, Janet E., Howard, Scott C.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990659/
https://ncbi.nlm.nih.gov/pubmed/24132809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phar.1360
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