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Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

To determine the pharmacologic importance of methotrexate (MTX) polyglutamates, we examined the formation, retention, and effect of these metabolites in cultured human breast cancer cells. Two cell lines (MCF-7 and ZR-75-B) converted the drug to γ-polyglutamate derivatives in a dose- and time-depend...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Jolivet, Jacques, Schilsky, Richard L., Bailey, Brenda D., Drake, James C., Chabner, Bruce A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 1982
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC371243/
https://ncbi.nlm.nih.gov/pubmed/6178756
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