Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

To determine the pharmacologic importance of methotrexate (MTX) polyglutamates, we examined the formation, retention, and effect of these metabolites in cultured human breast cancer cells. Two cell lines (MCF-7 and ZR-75-B) converted the drug to γ-polyglutamate derivatives in a dose- and time-depend...

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Dades bibliogràfiques

Publicat a:	J Clin Invest
Autors principals:	Jolivet, Jacques, Schilsky, Richard L., Bailey, Brenda D., Drake, James C., Chabner, Bruce A.
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical Investigation 1982
Matèries:	Articles
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371243/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6178756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110624
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