Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

To determine the pharmacologic importance of methotrexate (MTX) polyglutamates, we examined the formation, retention, and effect of these metabolites in cultured human breast cancer cells. Two cell lines (MCF-7 and ZR-75-B) converted the drug to γ-polyglutamate derivatives in a dose- and time-depend...

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Publicado en:J Clin Invest
Main Authors: Jolivet, Jacques, Schilsky, Richard L., Bailey, Brenda D., Drake, James C., Chabner, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 1982
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Articles
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371243/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6178756/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110624
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