Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

To determine the pharmacologic importance of methotrexate (MTX) polyglutamates, we examined the formation, retention, and effect of these metabolites in cultured human breast cancer cells. Two cell lines (MCF-7 and ZR-75-B) converted the drug to γ-polyglutamate derivatives in a dose- and time-depend...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Jolivet, Jacques, Schilsky, Richard L., Bailey, Brenda D., Drake, James C., Chabner, Bruce A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1982
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC371243/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6178756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110624
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