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Hyperglycemia Mediates a Shift From Cap-Dependent to Cap-Independent Translation Via a 4E-BP1–Dependent Mechanism

Diabetes and its associated hyperglycemia induce multiple changes in liver function, yet we know little about the role played by translational control of gene expression in mediating the responses to these conditions. Here, we evaluate the hypothesis that hyperglycemia-induced O-GlcNAcylation of the...

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Detalhes bibliográficos
Main Authors: Dennis, Michael D., Shenberger, Jeffrey S., Stanley, Bruce A., Kimball, Scot R., Jefferson, Leonard S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712054/
https://ncbi.nlm.nih.gov/pubmed/23434932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1453
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