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Hyperglycemia-Induced O-GlcNAcylation and Truncation of 4E-BP1 Protein in Liver of a Mouse Model of Type 1 Diabetes

4E-BP1 is a protein that, in its hypophosphorylated state, binds the mRNA cap-binding protein eIF4E and represses cap-dependent mRNA translation. By doing so, it plays a major role in the regulation of gene expression by controlling the overall rate of mRNA translation as well as the selection of mR...

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מידע ביבליוגרפי
Main Authors: Dennis, Michael D., Schrufer, Tabitha L., Bronson, Sarah K., Kimball, Scot R., Jefferson, Leonard S.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190771/
https://ncbi.nlm.nih.gov/pubmed/21840999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.259457
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