O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1–dependent mitochondrial dysfunction in the retina

Diabetes promotes the posttranslational modification of proteins by O-linked addition of GlcNAc (O-GlcNAcylation) to Ser/Thr residues of proteins and thereby contributes to diabetic complications. In the retina of diabetic mice, the repressor of mRNA translation, eIF4E-binding protein 1 (4E-BP1), is...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Dierschke, Sadie K., Miller, William P., Favate, John S., Shah, Premal, Imamura Kawasawa, Yuka, Salzberg, Anna C., Kimball, Scot R., Jefferson, Leonard S., Dennis, Michael D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462503/
https://ncbi.nlm.nih.gov/pubmed/30733333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007494
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi