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Human P-glycoprotein Contains a Greasy Ball-and-Socket Joint at the Second Transmission Interface
The P-glycoprotein drug pump protects us from toxins. Drug-binding sites in the transmembrane (TM) domains (TMDs) are connected to the nucleotide-binding domains (NBDs) by intracellular helices (IHs). TMD-NBD cross-talk is a key step in the transport mechanism because drug binding stimulates ATP hyd...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711299/ https://ncbi.nlm.nih.gov/pubmed/23733192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484550 |
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