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Human P-glycoprotein Contains a Greasy Ball-and-Socket Joint at the Second Transmission Interface

The P-glycoprotein drug pump protects us from toxins. Drug-binding sites in the transmembrane (TM) domains (TMDs) are connected to the nucleotide-binding domains (NBDs) by intracellular helices (IHs). TMD-NBD cross-talk is a key step in the transport mechanism because drug binding stimulates ATP hyd...

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Autori principali: Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711299/
https://ncbi.nlm.nih.gov/pubmed/23733192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484550
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