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The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE

Ansamycins are very effective HSP90 inhibitors that showed significant beneficial effects in the treatment of EAE. However, their toxicity and poor stability in solution limit their clinical use. In the present study we have characterized the anti-inflammatory properties of a novel HSP90 inhibitor,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lisi, Lucia, McGuire, Susan, Sharp, Anthony, Chiosis, Gabriela, Navarra, Pierluigi, Feinstein, Douglas L., Russo, Cinzia Dello
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710720/
https://ncbi.nlm.nih.gov/pubmed/23123171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.10.008
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