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The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE

Ansamycins are very effective HSP90 inhibitors that showed significant beneficial effects in the treatment of EAE. However, their toxicity and poor stability in solution limit their clinical use. In the present study we have characterized the anti-inflammatory properties of a novel HSP90 inhibitor,...

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Détails bibliographiques
Auteurs principaux: Lisi, Lucia, McGuire, Susan, Sharp, Anthony, Chiosis, Gabriela, Navarra, Pierluigi, Feinstein, Douglas L., Russo, Cinzia Dello
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710720/
https://ncbi.nlm.nih.gov/pubmed/23123171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.10.008
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