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The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-Loops containing DNA metabolism blocking lesions
Telomeres are critical for cell survival and functional integrity. Oxidative DNA damage induces telomeric instability and cellular senescence that are associated with normal aging and segmental premature aging disorders such as Werner Syndrome and Rothmund-Thompson Syndrome, caused by mutations in W...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710707/ https://ncbi.nlm.nih.gov/pubmed/23683351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.04.005 |
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