The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-Loops containing DNA metabolism blocking lesions

Telomeres are critical for cell survival and functional integrity. Oxidative DNA damage induces telomeric instability and cellular senescence that are associated with normal aging and segmental premature aging disorders such as Werner Syndrome and Rothmund-Thompson Syndrome, caused by mutations in W...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ferrarelli, Leslie K., Popuri, Venkateswarlu, Ghosh, Avik K., Tadokoro, Takashi, Canugovi, Chandrika, Hsu, Joseph K., Croteau, Deborah L., Bohr, Vilhelm A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710707/
https://ncbi.nlm.nih.gov/pubmed/23683351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.04.005
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