Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice

Cellular senescence refers to irreversible growth arrest of primary eukaryotic cells, a process thought to contribute to aging-related degeneration and disease. Deficiency of RecQ helicase RECQL4 leads to Rothmund–Thomson syndrome (RTS), and we have investigated whether senescence is involved using...

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Detalhes bibliográficos
Main Authors: Lu, H, Fang, E F, Sykora, P, Kulikowicz, T, Zhang, Y, Becker, K G, Croteau, D L, Bohr, V A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047874/
https://ncbi.nlm.nih.gov/pubmed/24832598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.168
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