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Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice
Cellular senescence refers to irreversible growth arrest of primary eukaryotic cells, a process thought to contribute to aging-related degeneration and disease. Deficiency of RecQ helicase RECQL4 leads to Rothmund–Thomson syndrome (RTS), and we have investigated whether senescence is involved using...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047874/ https://ncbi.nlm.nih.gov/pubmed/24832598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.168 |
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