A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome

Rett syndrome (RTT) results from loss-of-function mutations in the gene encoding the methyl-CpG-binding protein 2 (MeCP2) and is characterized by abnormal motor, respiratory and autonomic control, cognitive impairment, autistic-like behaviors and increased risk of seizures. RTT patients and Mecp2-nu...

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Main Authors: Schmid, Danielle A., Yang, Tao, Ogier, Michael, Adams, Ian, Mirakhur, Yatin, Wang, Qifang, Massa, Stephen M., Longo, Frank M., Katz, David M.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2012
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710112/
https://ncbi.nlm.nih.gov/pubmed/22302819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0865-11.2012
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