Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease

Repeated failures of “Aβ-lowering” therapies call for new targets and therapeutic approaches for Alzheimer's disease (AD). We propose to treat AD by halting neuronal death and repairing synapses using a BDNF-based therapy. To overcome the poor druggability of BDNF, we have developed an agonisti...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: Wang, Shudan, Yao, Hongyang, Xu, Yihua, Hao, Rui, Zhang, Wen, Liu, Hang, Huang, Ying, Guo, Wei, Lu, Bai
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7295064/
https://ncbi.nlm.nih.gov/pubmed/32550908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.44165
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