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Triptolide Induces the Expression of miR-142-3p: a Negative Regulator of Heat Shock Protein 70 and Pancreatic Cancer Cell Proliferation
Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest malignancies, is resistant to current chemotherapies. We previously showed that triptolide inhibits PDAC cell growth in vitro and blocks metastatic spread in vivo. Triptolide downregulates heat shock protein 70 (HSP70), a molecular chaper...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3707985/ https://ncbi.nlm.nih.gov/pubmed/23635652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1231 |
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