An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

BACKGROUND: A DNA methylation signature has been characterized that distinguishes rheumatoid arthritis (RA) fibroblast like synoviocytes (FLS) from osteoarthritis (OA) FLS. The presence of epigenetic changes in long-term cultured cells suggest that rheumatoid FLS imprinting might contribute to patho...

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Main Authors: Whitaker, John W, Shoemaker, Robert, Boyle, David L, Hillman, Josh, Anderson, David, Wang, Wei, Firestein, Gary S
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706831/
https://ncbi.nlm.nih.gov/pubmed/23631487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm444
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