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Regulation of DNA methylation in rheumatoid arthritis synoviocytes

INTRODUCTION: Rheumatoid arthritis (RA) is a chronic inflammatory disease in which fibroblast-like synoviocytes (FLS) exhibit an aggressive phenotype. While the mechanisms responsible are not well defined, epigenetics determinants such as DNA methylation might contribute. DNA methyltransferases (DNM...

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Hlavní autoři: Nakano, Kazuhisa, Boyle, David L., Firestein, Gary S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552038/
https://ncbi.nlm.nih.gov/pubmed/23277489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202572
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