Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes

c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activated protein kinase kinases (MEK) MKK4 and MKK7, which are, in turn, phosphorylated by MEK kin...

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Bibliographic Details
Main Authors: Hammaker, Deepa R, Boyle, David L, Inoue, Tomoyuki, Firestein, Gary S
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206340/
https://ncbi.nlm.nih.gov/pubmed/17559674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2215
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