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Synoviocyte Innate Immune Responses: I. Differential Regulation of Interferon Responses and the JNK Pathway by MAPK Kinases

JNK is a key regulator of matrix metalloproteinase production in rheumatoid arthritis. It is regulated by two upstream kinases known as MKK4 and MKK7. Previous studies demonstrated that only MKK7 is required for cytokine-mediated JNK activation and matrix metalloproteinase expression in cultured fib...

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Detalhes bibliográficos
Main Authors: Yoshizawa, Toshio, Hammaker, Deepa, Sweeney, Susan E., Boyle, David L., Firestein, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725405/
https://ncbi.nlm.nih.gov/pubmed/18713996
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