Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis

p38 mitogen-activated protein kinase (MAPK) regulates cytokines in arthritis and is, in turn, regulated by MAPK kinase (MKK) 3 and MKK6. To modulate p38 function but potentially minimize toxicity, we evaluated the utility of targeting MKK3 by using MKK3(−/−) mice. These studies showed that TNF-α inc...

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Detaylı Bibliyografya
Asıl Yazarlar: Inoue, Tomoyuki, Boyle, David L., Corr, Maripat, Hammaker, Deepa, Davis, Roger J., Flavell, Richard A., Firestein, Gary S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459381/
https://ncbi.nlm.nih.gov/pubmed/16567640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509188103
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