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Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6
BACKGROUND: Conventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation. In contrast, targeting the upstream MAP kinase kinases, MKK3 and MKK6, partially maintains p38-mediated anti-inf...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4030013/ https://ncbi.nlm.nih.gov/pubmed/24855454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-11-14 |
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